Liver tissue responses to gelatin and gelatin/chitosan gels | Zendy

Wang Xiaohong | Zendy; Yu Xin | Zendy; Yan Yongnian | Zendy; Zhang Renji | Zendy

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Liver tissue responses to gelatin and gelatin/chitosan gels

Author(s) -

Wang Xiaohong,

Yu Xin,

Yan Yongnian,

Zhang Renji

Publication year - 2008

Publication title -

journal of biomedical materials research part a

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.849

H-Index - 150

eISSN - 1552-4965

pISSN - 1549-3296

DOI - 10.1002/jbm.a.31712

Subject(s) - gelatin , biocompatibility , chitosan , glutaraldehyde , materials science , biodegradation , fibrin , liver tissue , polymer chemistry , biomedical engineering , chromatography , chemistry , biochemistry , medicine , organic chemistry , immunology , metallurgy

Gelatin and gelatin/chitosan gels, crosslinked using glutaraldehyde, were previously developed as substrates for three‐dimensional cell‐assembly techniques. In this study, the biocompatibility and biodegradation of gelatin and gelatin/chitosan gels were evaluated following implantation in rat livers for periods up to 16 weeks. The two gels were characterized by different inflammatory responses and degradation rates. The gelatin/chitosan gel is more efficient in inducing fibrin formation and vascularization at the implant‐host interface. The degrees of inflammatory reaction for the gelatin/chitosan gel were significantly stronger than the gelatin gel. Advanced biodegradation of the gelatin gels was observed. These data indicate that the gelatin gel has better liver tissue biocompatibility and a faster biodegraded rate than the gelatin/chitosan gel. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008

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