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Fabrication of fast responsive, thermosensitive poly( N ‐isopropylacrylamide) hydrogels by using diethyl ether as precipitation agent
Author(s) -
Xu XiaoDing,
Wang Bo,
Wang ZongChun,
Cheng SiXue,
Zhang XianZheng,
Zhuo RenXi
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31695
Subject(s) - self healing hydrogels , materials science , poly(n isopropylacrylamide) , lower critical solution temperature , chemical engineering , precipitation polymerization , polymerization , precipitation , swelling , polymer chemistry , radical polymerization , copolymer , composite material , polymer , physics , meteorology , engineering
An effective strategy was developed and demonstrated to improve the properties of thermosensitive poly( N ‐isopropylacrylamide) (PNIPAAm) hydrogel by using diethyl ether as a precipitation agent during the polymerization/crosslinking. Results reveal that the modified PNIPAAm hydrogels have the heterogeneous network structures and decreased LCSTs in a comparison with the normal PNIPAAm hydrogel. The modified PNIPAAm hydrogels also exhibit significantly improved sensitive properties, including fast response and stable, rapid, large magnitude oscillatory shrinking–swelling upon temperature cycles around lower critical solution temperature. In addition, fish DNA, used as a model drug, is loaded into the modified PNIPAAm hydrogels, the controlled release behaviors of the drug loaded hydrogels at different temperatures (22 and 37°C) are further examined. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2008