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Doxycycline sustained release from brushite cements for the treatment of periodontal diseases
Author(s) -
Tamimi Faleh,
Torres Jesús,
Bettini Ruggero,
Ruggera Francesca,
Rueda Carmen,
LópezPonce Manuel,
LopezCabarcos Enrique
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31610
Subject(s) - brushite , doxycycline , materials science , cement , biomaterial , porphyromonas gingivalis , actinobacillus , bone cement , dentistry , antibiotics , microbiology and biotechnology , periodontitis , calcium , metallurgy , medicine , nanotechnology , biology
Abstract Doxycycline (DOXY) is a wide spectrum antibiotic used in the treatment of dental, periodontal, and bone infections. Brushite cements are calcium phosphate biomaterials especially interesting for bone regeneration processes. In this work, we describe the preparation of a brushite cement containing DOXY and the drug release from the cement. DOXY solutions were mixed with the cement powder and after a 50% burst release in the first 12 h, a slow and controlled release was achieved over 3.5 days. The release of DOXY hyclate was controlled by both, diffusion and Ca 2+ interaction. Formation of DOXY‐Ca 2+ chelates was detected in the cement structure using solid state fluorescence. The brushite cement loaded with DOXY hyclate had antibacterial activity against periodontal pathogens: Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Bacteroides frosthytus . This new biomaterial may be helpful for the treatment of periodontal diseases. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008