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Biological response of tissues with macrophagic activity to titanium dioxide
Author(s) -
Olmedo Daniel G.,
Tasat Deborah R.,
Evelson Pablo,
Guglielmotti María B.,
Cabrini Rómulo L.
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31514
Subject(s) - rutile , anatase , titanium dioxide , materials science , titanium , spleen , reactive oxygen species , chemical engineering , biophysics , metallurgy , biochemistry , immunology , biology , photocatalysis , engineering , catalysis
The titanium dioxide layer is composed mainly of anatase and rutile. This layer is prone to break, releasing particles to the milieu. Therefore, corrosion may cause implant failure and body contamination. We have previously shown that commercial anatase–titanium dioxide (TiO 2 –anatase) is deposited in organs with macrophagic activity, transported in the blood by phagocytic‐mononuclear cells, and induces an increase in the production of reactive oxygen species (ROS). In this study, we evaluated the effects of rutile–titanium dioxide (TiO 2 –rutile). Male Wistar rats were injected i.p. with a suspension of TiO 2 –rutile powder at a dose of 1.60 g/100 g b.w. Six months postinjection, the presence of Ti was assessed in serum, blood cells, liver, spleen, and lung. Titanium was found in phagocytic mononuclear cells, serum, and in the parenchyma of all the organs tested. TiO 2 –rutile generated a rise in the percentage of reactive cells, which was smaller than that observed when TiO 2 –anatase was employed in a previous study. Although TiO 2 –rutile provoked an augmentation of ROS, it failed to induce damage to membrane lipids, possibly due to an adaptive response. The present study reveals that TiO 2 –rutile is less bioreactive than TiO 2 –anatase. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008