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Preparation and surface characterization of HMDI‐activated 316L stainless steel for coronary artery stents
Author(s) -
Chuang T.W.,
Chen M.H.,
Lin F.H.
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31451
Subject(s) - materials science , fourier transform infrared spectroscopy , triethoxysilane , hexamethylene diisocyanate , nuclear chemistry , amine gas treating , surface modification , chemical engineering , composite material , polyurethane , chemistry , organic chemistry , engineering
Poor compatibility between blood and metallic coronary artery stents is one reason for arterial restenosis. Immobilization of anticoagulant agents on the stent's surface is feasible for improving compatibility. We examined possible surface‐coupling agents for anticoagulant agent immobilization. Hexamethylene diisocyanate (HMDI) and 3‐aminopropyl‐triethoxysilane (APTS) were examined as surface‐coupling agents to activate 316L stainless steel (e.g., stent material). The activated surface was characterized using Fourier transformation infrared spectroscopy (FTIR), atomic force microscope (AFM), surface plasmon resonance (SPR), and trinitrobenzene sulfonic acid (TNBS) assay. In FTIR analysis, HMDI and APTS were both covalently linked to 316L stainless steel. In AFM analysis, it was found that the HMDI‐activated surface was smoother than the APTS‐activated one. In SPR test, the shift of SPR angle for the APTS‐activated surface was much higher than that for the HMDI‐activated surface after being challenged with acidic solution. TNBS assay was used to determine the amount of immobilized primary amine groups. The HMDI‐activated surface was found to consist of about 1.32 μmol/cm 2 amine group, whereas the APTS‐activated surface consisted of only 0.89 μmol/cm 2 amine group. We conclude that the HMDI‐activated surface has more desirable surface characteristics than the APTS‐activated surface has, such as chemical stability and the amount of active amine groups. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008