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Hybrid nanofibrous membranes of PLGA/chitosan fabricated via an electrospinning array
Author(s) -
Duan Bin,
Wu Lili,
Yuan Xiaoyan,
Hu Zhen,
Li Xiulan,
Zhang Yang,
Yao Kangde,
Wang Min
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31408
Subject(s) - chitosan , plga , membrane , electrospinning , materials science , chemical engineering , nanofiber , tissue engineering , polymer , polymer chemistry , biomedical engineering , composite material , nanotechnology , chemistry , nanoparticle , medicine , biochemistry , engineering
Abstract Hybrid nanofibrous membranes of poly(lactic‐ co ‐glycolic acid) (PLGA) and chitosan with different chitosan amounts (32.3, 62.7, and 86.5%) were fabricated via a specially designed electrospinning setup consisting of two sets of separate syringe pumps and power supplies. After soaking in chloroform overnight to dissolve PLGA, the amount of chitosan in the hybrid membranes was determined. The structure, mechanical properties, water uptake, and cytocompatibilities of the nanofibrous membranes were investigated by scanning electron microscopy, tensile testing, incubation in phosphate buffer solution, and human embryo skin fibroblasts culturing. Results showed that the chitosan amount in PLGA/chitosan membranes could be well controlled by adjusting the number of syringe for electrospinning of PLGA or chitosan, respectively. Because of the introduction of chitosan, which is a naturally hydrophilic polymer, the hybrid PLGA/chitosan membranes after chitosan crosslinking exhibited good mechanical and water absorption properties. The cytocompatibility of hybrid PLGA/chitosan membranes was better than that of the electrospun PLGA membrane. The electrospun hybrid nanofibrous membranes of PLGA and chitosan appear to be promising for skin tissue engineering. The concept of using an electrospinning array to form multicomponent nanofibrous membranes will lead to the creation of novel scaffolds for tissue engineering applications. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007