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Pasty injectable biodegradable polymers derived from natural acids
Author(s) -
Krasko Michal Y.,
Domb Abraham J.
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31395
Subject(s) - ricinoleic acid , polymer , materials science , biodegradable polymer , organic chemistry , copolymer , melting point , polymer chemistry , transesterification , chemistry , castor oil , composite material , catalysis
Pasty biodegradable polymers that can be mixed with drugs at room temperature and injected to tissue as neat composition are advantageous as they allow simple preparation and delivery of drugs, particularly for heat sensitive drugs. A series of biodegradable pasty poly (ester‐anhydride)s were prepared from alkanedicarboxylic acids and ricinoleic acid and its oligomers by transesterification‐repolymerization method. The polymers were characterized by common spectroscopic, chromatography, and thermal methods. Polymers containing 70% ricinoleic acid and 30% linear dicarboxylic acids with 4‐10 methylene groups were synthesized. The melting point of these poly (ester‐anhydride)s increased as the number of methylenes in the alkanedicarboxylic acid increased. Use of short oligomers of ricinoleic acid instead of ricinoleic acid itself increased the melting point and decreased the softness of the resulting polymers. The polymers released model drugs for a few weeks while being degraded to their fatty acid counterparts. Copolymerization of alkanedicarboxylic acids with ricinoleic acid resulted in pasty biodegradable polymers useful as injectable carriers for drugs. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007