Premium
An optimized β‐tricalcium phosphate and agarose scaffold fabrication technique
Author(s) -
Román J.,
Cabañas M.V.,
Peña J.,
Doadrio J.C.,
ValletRegí M.
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31394
Subject(s) - materials science , fabrication , scaffold , agarose , phosphate , biomedical engineering , composite material , nanotechnology , chromatography , organic chemistry , pathology , medicine , chemistry , alternative medicine
Biodegradable scaffolds composed of β‐tricalcium phosphate, and a natural hydrogel, agarose, were prepared by a shaping method based on the thermal gelation of the polymeric component. This technique was modified to facilitate the inclusion, during the scaffold preparation stage, of therapeutic agents that could improve the graft performance. Vancomycin was included in materials containing different amounts of agarose and ceramic without affecting the scaffold consolidation process. These materials, easily injectable, behave like a reinforced hydrogel whose swelling behavior and drug release rate depend on their composition. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008