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Synthesis, characterization, and hydrolytic degradation behavior of a novel biodegradable pH‐sensitive hydrogel based on polycaprolactone, methacrylic acid, and poly(ethylene glycol)
Author(s) -
Chao Guo Tao,
Qian Zhi Yong,
Huang Mei Juan,
Kan Bing,
Gu Ying Chun,
Gong Chang Yang,
Yang Jin Liang,
Wang Ke,
Dai Mei,
Li Xing Yi,
Gou Ma Ling,
Tu Ming Jing,
Wei Yu Quan
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31362
Subject(s) - materials science , self healing hydrogels , swelling , ethylene glycol , hydrolysis , polycaprolactone , fourier transform infrared spectroscopy , chemical engineering , methacrylic acid , polymer chemistry , degradation (telecommunications) , aqueous solution , polymerization , scanning electron microscope , polymer , organic chemistry , composite material , chemistry , telecommunications , computer science , engineering
In this work, a new kind of biodegradable pH‐sensitive hydrogel was successfully synthesized by UV‐initiated free radical polymerization. The obtained hydrogel was characterized by 1 H NMR and FTIR. Swelling behavior in different aqueous media and pH responsivity of the hydrogels were studied in detail as well. With increase in pH from 1.2 to 7.2, swelling ratio of the hydrogel increased. The morphology was observed by scanning electron microscopy, and the hydrolytic degradation behavior was also investigated in this work. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2008