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Degradable block polyurethanes from nontoxic building blocks as scaffold materials to support cell growth and proliferation
Author(s) -
Rechichi A.,
Ciardelli G.,
D'Acunto M.,
Vozzi G.,
Giusti P.
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31349
Subject(s) - materials science , adhesion , biocompatible material , tissue engineering , scaffold , fibroblast , cell adhesion , characterization (materials science) , cell growth , polymer , biomaterial , polyurethane , nanotechnology , in vitro , biophysics , biomedical engineering , composite material , chemistry , biochemistry , biology , medicine
Linear degradable polyurethanes were prepared and proposed for tissue engineering applications. Biocompatible segments were selected for the synthesis to promote their integration with the biological environment. Physicochemical and morphological characterization (SEC, DSC, DMTA, AFM) revealed that the properties of these polymeric systems can be easily tuned by varying the nature and the composition of the constituent segments. In vitro biological assays (citotoxicity, fibroblast adhesion, and proliferation) showed that all polymers are not toxic, promoting the adhesion and proliferation of fibroblast cells, with slight differences depending on the material hydrophilicity. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008