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Bactericidal activity of chlorine‐loaded carbide‐derived carbon against Escherichia coli and Bacillus anthracis
Author(s) -
Gogotsi Yury,
Dash Ranjan Kumar,
Yushin Gleb,
Carroll Beth E.,
Altork Susan Rachel,
SassiGaha Sihem,
Rest Richard F.
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31321
Subject(s) - chlorine , nanoporous , bacillus anthracis , carbide , bacteria , microbiology and biotechnology , carbon fibers , metal , materials science , escherichia coli , nuclear chemistry , chemistry , biology , nanotechnology , metallurgy , composite number , biochemistry , composite material , gene , genetics
The authors investigated the bactericidal activity of high‐chlorine‐content nanoporous carbide‐derived carbon (CDC) against the Gram‐positive, spore‐forming bacterium Bacillus anthracis and the common Gram‐negative enteric bacterium Escherichia coli. Chlorine‐loaded nanoporous CDC produced by thermochemical etching of metals and metalloids by chlorination of carbides can retain up to 40 wt % of chlorine. Etching temperature and the structure and composition of carbides allow tuning the porosity of CDC. The CDC chlorine content depends on the synthesis temperature, pore size, and metal carbide used during preparation. It was observed that chlorine‐loaded CDC killed up to 100% of exposed E. coli and B. anthracis spores and vegetative cells in a dose and time‐dependent manner. CDC containing higher concentrations of chlorine killed bacteria to a greater extent and faster than did CDC containing lesser concentrations of chlorine. The results suggest that chlorine‐loaded CDC can be used inseveral commercial, defense, and industrial activities andprocesses to kill bacteria. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008