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Acyclic N ‐halamine‐based biocidal tubing: Preparation, characterization, and rechargeable biofilm‐controlling functions
Author(s) -
Luo Jie,
Sun Yuyu
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31301
Subject(s) - ceric ammonium nitrate , materials science , methacrylamide , nuclear chemistry , biofilm , ammonium persulfate , polymer chemistry , titration , ammonium , grafting , chemical engineering , organic chemistry , bacteria , polymerization , chemistry , copolymer , composite material , acrylamide , biology , engineering , genetics , polymer
In this study, the surfaces of polypropylene tubing were hydroxylated with potassium persulfate. The resultant tubing surfaces were grafted with methacrylamide (MAA) using ceric(IV) ammonium nitrate as an initiator. Upon chlorination treatment with diluted chlorine bleach, some of the amide groups in the grafted MAA side chains were transformed into stable acyclic N ‐halamines. The reactions were confirmed with attenuated total reflectance infrared, X‐ray photoelectron spectra, and iodimetric titration. The resultant tubing was challenged with Pseudomonas aeruginosa ( P. aeruginosa ) in a continuous flowing model. Bacteria culturing and scanning electron microscope studies showed that the chlorinated MAA‐grafted tubing could provide potent and rechargeable biofilm‐controlling functions against the test microorganisms. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008