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Bone response to three different chemical compositions of fluorcanasite glass‐ceramic
Author(s) -
da Rocha Barros Valdemar Mallet,
Liporaci Jorge Luiz J.,
Rosa Adalberto L.,
Junqueira Marcela Caffarena,
de Oliveira Paulo Tambasco,
Johnson Anthony,
van Noort Richard
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31219
Subject(s) - materials science , ceramic , bioactive glass , glass ceramic , fluorapatite , biomaterial , bone tissue , composite material , biomedical engineering , connective tissue , dentistry , apatite , mineralogy , chemistry , medicine , nanotechnology , pathology
The aim of this study was to evaluate the bone response to three fluorcanasite glass‐ceramic compositions with different solubilities (K3, K5, and K8) after implantation in a femur rabbit model. Fluorcanasite glass‐ceramic rods were implanted bilaterally in the mid‐shafts rabbit femurs. Implants were harvested at 8 and 12 weeks and prepared for histological and histomorphometric analyses at the light microscope level. Bioglass 45S5 rods were used as a control material. At 8 weeks, all fluorcanasite glass‐ceramics were entirely surrounded by a nonmineralized connective tissue. At 12 weeks, reduced areas of bone tissue were observed in the cortical area in direct contact with the K3 and K5 fluorcanasite glass‐ceramics compared to Bioglass 45S5, whereas no bone tissue was observed in direct contact with the K8 surface. Bone‐to‐implant contact in the cortical area was affected by the material chemical composition and ranked as follows: Bioglass 45S5 > K3 > K5 > K8 ( p = 0.001). In the bone marrow, a layer of fibrous connective tissue formed in direct contact with the fluorcanasite glass‐ceramics and Bioglass 45S5, and only rarely exhibited contact osteogenesis. All the fluorcanasite glass‐ceramics appeared to degrade in the biological environment. The solubility ratio did not alter significantly the biological reply of the fluorcanasite glass‐ceramics in vivo . Further modifications of the chemical composition of the fluorcanasite glass‐ceramic are required to increase the stability of the material in vivo . © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007