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The diffusion process of sodium hyaluronate (Na‐Ha) and Na‐Ha‐ n ‐alkyl derivatives films swelling
Author(s) -
Mráček Aleš,
Benešová Karolína,
Minařík Antonín,
Urban Pavel,
Lapčík Lubomír
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31188
Subject(s) - swelling , materials science , enthalpy , diffusion , polymer , polymer chemistry , sodium , alkyl , thermodynamics , solvent , kinetics , chemical engineering , organic chemistry , composite material , chemistry , physics , quantum mechanics , engineering , metallurgy
The process of diffusion of sodium hyaluronate and its hydrophobically modified alkyl derivatives in water was studied by measuring the kinetics of solid polymer film swelling. The following fundamental thermodynamic parameters of the swelling process were calculated: the apparent diffusion coefficient of swelling by water D s determined at three temperatures (25, 37, and 45°C), the activation enthalpy of diffusion connected with the swelling Δ H D,s and the activation enthalpy of the swelling process Δ H s . The thermodynamic activity of the solvent for the given sodium hyaluronate and its four alkyl derivatives has been expressed through the internal quantity RA δ,s , that is expansion work of polymer coil accomplished by the action of the internal pressure. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007