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Modulation of zinc release from bioactive sol–gel derived SiO 2 ‐CaO‐ZnO glasses and ceramics
Author(s) -
Jaroch D.B.,
Clupper D.C.
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31180
Subject(s) - simulated body fluid , materials science , zinc , calcium , amorphous solid , phosphate , amorphous calcium phosphate , ceramic , sol gel , nuclear chemistry , adsorption , zinc phosphate , mineralogy , chemical engineering , analytical chemistry (journal) , metallurgy , chromatography , nanotechnology , composite material , scanning electron microscope , crystallography , chemistry , organic chemistry , engineering
Zinc is an essential trace element which may be effective in promoting hard tissue healing. Glasses in the SiO 2 ‐CaO‐ZnO system were synthesized via sol–gel methods. Using a constant silica content (70 mol %), the ratio of Ca to Zn was varied (1.5, 3.5, or 6.5), as was the stabilization temperature (650, 750, or 850°C), to examine such effects on the bioactive response and zinc release in simulated body fluid (SBF). XRD revealed the development of CaSiO 3 and Ca 2 ZnSi 2 O 7 crystalline phases during stabilization at 850°C only. N 2 adsorption analysis determined that the specific surface area (BET) varied between 14 and 179 m 2 /g and was dependent on composition and stabilization temperature, as was the average initial pore size (51–125 Å). The formation of hydroxycarbonate (HCA) and amorphous calcium phosphate (ACP) was observed at 14 days for samples stabilized at 650 or 750°C. Only ACP layers were observed on such samples prior to 14 day. Relative to the Ca levels at 14 day (60–485 μg/ml), Zn levels in solution were relatively low (0.06–1.18 μg/ml). EDX and ICP data suggested that released Zn was incorporated into the forming calcium phosphate reaction layer, thereby preventing concentrations of the essential trace element from reaching potentially toxic levels. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007