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Biomedical modification of poly( L ‐lactide) by blending with lecithin
Author(s) -
Zhu N.,
Cui F.Z.,
Hu K.,
Zhu L.
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31159
Subject(s) - materials science , lactide , polymer science , chemical engineering , biomedical engineering , composite material , copolymer , polymer , medicine , engineering
Lecithin was, for the first time, blended with PLLA to prepare scaffold material for tissue engineering applications in the present study. Solution blending was used to incorporate Lecithin (containing 0–10 wt %) with PLLA to enhance the blend films biocompatibility, hydrophilicity and toughness while maintaining mechanical strength of PLLA. The results of FTIR‐ATR analysis indicated that the amino groups of lecitin existed in the films. DSC analysis indicated that T g decreased with the increase of lecithin content in the blend films. The percentage elongation markedly increased with increase of lecithin content. The proliferation and viability of the vascular smooth muscle cell cultures on PLLA/Lecithin (containing 3–7 wt %) films were significantly enhanced compared to pure PLLA on tissue culture plates. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007