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CaTiO 3 coating on titanium for biomaterial application—Optimum thickness and tissue response
Author(s) -
Ohtsu Naofumi,
Sato Kenji,
Yanagawa Aya,
Saito Kesami,
Imai Yoshio,
Kohgo Takao,
Yokoyama Atsuro,
Asami Katsuhiko,
Hanawa Takao
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31136
Subject(s) - materials science , biocompatibility , biomaterial , titanium , biomedical engineering , calcium , calcium titanate , composite material , nanotechnology , metallurgy , ceramic , medicine
The objectives of this study were to determine the optimum thickness of a CaTiO 3 film for biomaterial applications and to investigate the biocompatibility and bone formation of titanium with a CaTiO 3 film. First, CaTiO 3 films of 10, 20, 30, and 50 nm in thickness were deposited on titanium substrates using radiofrequency magnetron sputtering followed by annealing at 873 K in air for 7.2 ks. The optimum thickness of the CaTiO 3 film for bone formation was determined by comparison with its performance regarding calcium phosphate formation in Hanks' balanced saline solution (HBSS). Regarding calcium phosphate formation, the performance of the specimen with a 50‐nm‐thick CaTiO 3 film was superior to those of specimens with other thicknesses. A titanium prism with a CaTiO 3 film of 50‐nm in thickness was surgically inserted in both soft and hard rat tissues. The biocompatibility of CaTiO 3 ‐deposited titanium and bone formation on it was investigated by histological observations. A slight inflammatory reaction was observed around the titanium with the 50‐nm‐thick CaTiO 3 film, while no severe response, such as degeneration and necrosis, was observed in either soft or hard rat tissue. New bone formation on the titanium plate with the CaTiO 3 film was more active than that without the film. The 50‐nm‐thick CaTiO 3 film has biocompatibility and can facilitate new bone formation in vivo , and, consequently, it is an excellent surface modification method for biomaterial applications. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007