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Selective cell proliferation can be controlled with CPC particle coatings
Author(s) -
Szivek J.A.,
Margolis D.S.,
Schnepp A.B.,
Grana W.A.,
Williams S.K.
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31116
Subject(s) - cell growth , chondrocyte , materials science , chondrogenesis , cartilage , scaffold , microbiology and biotechnology , angiogenesis , biomedical engineering , cell , anatomy , medicine , chemistry , biology , cancer research , biochemistry
Abstract To develop implantable, engineered, cartilage constructs supported by a scaffold, techniques to encourage rapid tissue growth into, and on the scaffold are essential. Preliminary studies indicated that human endothelial cells proliferated at different rates on different calcium phosphate ceramic (CPC) particles. Judicious selection of particles may encourage specific cell proliferation, leading to an ordered growth of tissues for angiogenesis, osteogenesis, and chondrogenesis. The goal of this study was to identify CPC surfaces that encourage bone and vascular cell growth, and other surfaces that support chondrocyte growth while inhibiting proliferation of vascular cells. Differences in bone and vascular cell proliferation were observed when using epoxy without embedded CPCs to encourage bone cells, and when three CPCs were tested, which encouraged vascular cell proliferation. One of these (CPC 7) also substantially depressed cartilage cell proliferation. Only one small‐diameter crystalline CPC (CPC 2) supported rapid chondrocyte proliferation, and maintained the cartilage cell phenotype. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007