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Fabrication and characterization of hydrophilic electrospun membranes made from the block copolymer of poly(ethylene glycol‐ co ‐lactide)
Author(s) -
Yang DeJuan,
Zhang LiFang,
Xu Liang,
Xiong ChengDong,
Ding Jing,
Wang YuZhong
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31099
Subject(s) - materials science , copolymer , membrane , electrospinning , ethylene glycol , differential scanning calorimetry , contact angle , polymer chemistry , chemical engineering , polymer , fiber , peg ratio , composite material , chemistry , biochemistry , physics , finance , engineering , economics , thermodynamics
To improve the hydrophilicity, pliability, and egradability of some biodegradable polymers such as polylactide (PLA), a triblock copolymer, and poly(ethylene glycol‐ co ‐lactide) (PELA) has been electrospun into fibrous membranes in the fiber sizes of 7.5 μm to 250 nm. The relationship between electrospinning parameters (such as voltage, concentration, and feeding rate) and the fiber diameters has been investigated. The characterizations for the structure and morphology of electrospun membranes were carried out using differential scanning calorimetry (DSC), 1 H NMR, and scanning electron microscopy (SEM). The hydrophilicity of the membrane was determined by contact angle measurements in bidistilled water, and it was shown that the hydrophilicity of the copolymer could be adjusted by the content of the poly (ethylene glycol) (PEG) segment in the copolymer. The results of in vitro degradation study showed that the submicrostructure of the fibrous membrane and the incorporation of hydrophilic PEG into PLA block could accelerate the degradation of the membrane in regards to the changes of inherent viscosity, tensile strength, and weight loss. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007