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Porous polylactide/chitosan scaffolds for tissue engineering
Author(s) -
Wan Ying,
Fang Ya,
Wu Hua,
Cao Xiaoying
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31025
Subject(s) - materials science , chitosan , porosity , swelling , tissue engineering , composite material , solvent , chemical engineering , toughness , biomedical engineering , organic chemistry , chemistry , medicine , engineering
Novel porous scaffolds were fabricated using biodegradable polylactide/chitosan blends. A combinational technique involving solvent‐extracting, liquid‐solid separation, and freeze‐drying paths were employed. The processing parameters were optimized in order to produce desired porous scaffolds and thus obtained scaffolds showed well distributed and interconnected porous structures with controllable porosities varying from around 50–85% and regulative pore sizes being distributed within a region between 2 and 190 μm. These scaffolds exhibited remarkably improved hydrophilicity based on the measurements for their swelling index. The results obtained from in vitro incubation of scaffolds in phosphate buffered saline solutions at 37°C during various periods up to 10 weeks indicated that chitosan component inside the scaffolds, on the one hand, effectively buffered the acidic degradation products of polylactide/chitosan scaffolds and on the other hand, the degradation of the scaffolds was also conspicuously delayed. These porous scaffolds maintained well‐defined compressive mechanical properties and by well‐blending polylactide with chitosan component, improved toughness on the resultant porous scaffolds was also observed. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006