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Biocompatible superparamagnetic iron oxide nanoparticle dispersions stabilized with poly(ethylene glycol)–oligo(aspartic acid) hybrids
Author(s) -
Wan Shourong,
Huang Junsheng,
Guo Miao,
Zhang Hongkai,
Cao Youjia,
Yan Husheng,
Liu Keliang
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31022
Subject(s) - ethylene glycol , superparamagnetism , materials science , nanoparticle , ethylene oxide , iron oxide nanoparticles , acrylic acid , nuclear chemistry , polymer chemistry , copolymer , iron oxide , magnetic nanoparticles , chemical engineering , nanotechnology , chemistry , polymer , physics , magnetization , quantum mechanics , magnetic field , engineering , composite material , metallurgy
Methoxypoly(ethylene glycol)–oligo(aspartic acid) (MPEG–Asp n ‐NH 2 , n = 2–5) hybrid block copolymers were synthesized and used as stabilizers to prepare superparamagnetic Fe 3 O 4 nanoparticles with magnetite as the inner core and and poly(ethylene glycol) as the hydrophilic outer shell. The aqueous dispersions of the nanoparticles were stable at pH 2–11 and in 1 M NaCl solution, when repeat number, n , was 3 or more. Transmission electron microscopy showed that the nanoparticles, stabilized with MPEG–Asp 3 ‐NH 2 , were about 14 nm in diameter. Magnetic measurements indicated that MPEG–Asp 3 ‐NH 2 ‐coated iron oxide nanoparticles showed superparamagnetic behavior. Cell adhesion assay and in vitro cell viability/cytotoxicity studies showed that MPEG–Asp 3 ‐NH 2 ‐coated iron oxide nanoparticles had less effect on cell adhesion/viability and morphology, and less cytotoxicity compared with uncoated, poly (acrylic acid)‐coated, and MPEG–poly(acrylic acid)‐coated iron oxide nanoparticles. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006