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Water soluble complexes of chitosan‐ g ‐MPEG and hyaluronic acid
Author(s) -
Wu Jun,
Wang Xuefen,
Keum Jong Kahk,
Zhou Hongwen,
Gelfer Mikhail,
AvilaOrta CarlosAlberto,
Pan Hui,
Chen Weiliam,
Chiao ShuMin,
Hsiao Benjamin S.,
Chu Benjamin
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30972
Subject(s) - materials science , hyaluronic acid , chitosan , rheology , biocompatibility , chemical engineering , ethylene glycol , viscosity , polyelectrolyte , lamellar structure , polymer chemistry , polymer , composite material , genetics , engineering , metallurgy , biology
Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS‐ g ‐MPEG) and negatively charged hyaluronic acid (HA). CS‐ g ‐MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG‐aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS‐ g ‐MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS‐ g ‐MPEG solution. The highest viscosity was obtained when the charge ratio of CS‐ g ‐MPEG/HA was close to 1.0. Small‐angle X‐ray scattering measurements provided some insights into the lamellar structure of the CS‐ g ‐MPEG/HA complex. The CS‐ g ‐MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium). © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006