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In vitro degradation of biodegradable blending materials based on poly( p ‐dioxanone) and poly(vinyl alcohol)‐graft‐poly( p ‐dioxanone) with high molecular weights
Author(s) -
Chen SiChong,
Wang XiuLi,
Wang YuZhong,
Yang KeKe,
Zhou ZhiXuan,
Wu Gang
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30938
Subject(s) - copolymer , materials science , vinyl alcohol , differential scanning calorimetry , degradation (telecommunications) , crystallization , polymer chemistry , crystallinity , chemical engineering , intrinsic viscosity , composite material , polymer , telecommunications , physics , computer science , engineering , thermodynamics
Amphiphilic biodegradable graft copolymer, poly(vinyl alcohol)‐graft‐poly( p ‐dioxanone) (PVA‐g‐PPDO), was used to prepare a new biodegradable material by blending with poly( p ‐dioxanone) (PPDO). The in vitro degradation properties of the copolymer and blends with different contents of PVA‐g‐PPDO were studied in phosphate buffer at 37°C. The degradation processes of the PVA‐g‐PPDO and its blends with the PPDO were monitored by weight loss, viscosimetry, water uptake, differential scanning calorimetry (DSC), and scanning electron microscopy. The results of inherent viscosity and weight loss reveal that the PVA‐g‐PPDO has a different in vitro degradation behavior from that of PPDO, and the introducing of copolymer into the blending system may enhance the degradability of PPDO when the contents of copolymer is higher than 5%. The change of the degree of crystallization ( D c ) of copolymer and blends derived from the DSC also shows that the copolymer and blends have faster degradation rates than the neat PPDO during the testing period. A degradation mechanism of the blends was postulated based on the results of the weight retention, inherent viscosity measurement, and DSC. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007