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Peri‐implant bone formation and implant integration strength of peptide‐modified p(AAM‐ co ‐EG/AAC) interpenetrating polymer network‐coated titanium implants
Author(s) -
Barber Thomas A.,
Ho James E.,
De Ranieri Aladino,
Virdi Amarjit S.,
Sumner Dale R.,
Healy Kevin E.
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30927
Subject(s) - materials science , implant , bone sialoprotein , medullary cavity , interpenetrating polymer network , biomedical engineering , in vivo , ethylene glycol , titanium , bone healing , fixation (population genetics) , polymer , osteocalcin , composite material , chemistry , surgery , alkaline phosphatase , anatomy , medicine , biology , biochemistry , microbiology and biotechnology , organic chemistry , gene , metallurgy , enzyme
Interpenetrating polymer networks (IPNs) of poly (acrylamide‐ co ‐ethylene glycol/acrylic acid) functionalized with an ‐Arg‐Gly‐Asp‐ (RGD) containing 15 amino acid peptides, derived from rat bone sialoprotein (bsp‐RGD(15), were grafted to titanium implants in an effort to modulate bone formation in the peri‐implant region in the rat femoral ablation model. Bone–implant contact (BIC) and bone formation within the medullary canal were determined using microcomputed tomography at 2 and 4 weeks postimplantation. BIC for bsp‐RGD(15)‐IPN implants was enhanced relative to hydroxyapatite tricalcium phosphate (HA‐TCP) coated implants, but was similar to all other groups. Aggregate bone formation neither indicated a dose‐dependent effect of bsp‐RGD(15) nor a meaningful trend. Mechanical testing of implant fixation revealed that only the HA‐TCP coated implants supported significant (>1 MPa) interfacial shear strength, despite exhibiting lower overall BIC, an indication that bone ingrowth into the rougher coating was the primary mode of implant fixation. While no evidence was found to support the hypothesis that bsp‐RGD(15)‐modified IPN coated implants significantly impacted bone–implant bonding, these results point to the lack of correlation between in vitro studies employing primary osteoblasts and in vivo wound healing in the peri‐implant region. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007