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Cytotoxicity of partial‐stabilized cement
Author(s) -
Wang WenHsi,
Lin FengHuei,
Lee YuanLing,
Lin ChunPin
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30919
Subject(s) - cytotoxicity , mineral trioxide aggregate , materials science , cement , dental cement , osteoblast , metal , calcium silicate , calcium , dentistry , nuclear chemistry , composite material , metallurgy , medicine , chemistry , biochemistry , in vitro , adhesive , layer (electronics)
Partial‐stabilized cement (PSC) is a kind of modified calcium silicate cement used for root‐end surgery. Minor transition metal elements Co, Cr, and Zn were added for enhancing the setting property of to PSC. In our previous study, minor transition metal additions greatly improved the setting property of PSC. However, the concern of metal toxicity was raised, as the material would be used in the human body. In this study, we evaluated the cytotoxicity of PSC in comparison with mineral trioxide aggregate (MTA), which is one of the commercialized materials used for dental root‐end filling. Primary osteoblast cell was used as the target cell. Cell proliferation, cytotoxicity, viability, function, and senescence were analyzed. The cytotoxicity of the PSC‐Zn group (PSC with Zn addition) was similar to that of MTA. PSC‐Zn is not only nontoxic at the cellular level but also has adequate mechanical property, which makes it a potential root‐end filling material for apical surgery. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res 2007