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A novel synthetic tissue‐adhesive hydrogel using a crosslinkable polymeric micelle
Author(s) -
Murakami Yoshihiko,
Yokoyama Masayuki,
Okano Teruo,
Nishida Hiroshi,
Tomizawa Yasuko,
Endo Masahiro,
Kurosawa Hiromi
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30911
Subject(s) - materials science , micelle , adhesive , ethylene glycol , polymer , self healing hydrogels , aldehyde , polymer chemistry , peg ratio , surface modification , chemical engineering , organic chemistry , nanotechnology , aqueous solution , composite material , chemistry , catalysis , layer (electronics) , finance , engineering , economics
Abstract We prepared a novel tissue‐adhesive hydrogel by using a polymeric micelle consisting of an aldehyde‐terminated poly(ethylene glycol)–poly( D , L ‐lactide) (PEG–PLA) block polymer. A Schiff base is chemically formed between the amino groups in a polyallylamine and the aldehyde groups on the surface of polymeric micelles. The hydrogel was formed in ∼2 s when the polymeric micelle solution and polyallylamine solution are mixed in vitro . The hydrogel was rapidly formed in vivo , and it adhered to a tissue surface. Our novel tissue‐adhesive hydrogel creates no risk of infectious contaminations, because it consists of only synthetic materials. Further, PEG and PLA are known to be biocompatible and noncytotoxic. The results obtained in the present study show that a hydrogel prepared by the formation of a Schiff base between aldehyde and amine groups will potentially address the need for novel tissue‐adhesive materials. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007