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Plasma deposition of tetraglyme inside small diameter tubing: Optimization and characterization
Author(s) -
Cao Lan,
Ratner Buddy D.,
Horbett Thomas A.
Publication year - 2007
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30906
Subject(s) - materials science , coating , ether , deposition (geology) , adsorption , polyethylene , adhesion , composite material , chemical engineering , carbon fibers , analytical chemistry (journal) , chromatography , organic chemistry , composite number , sediment , engineering , biology , paleontology , chemistry
Abstract In this study, a glow discharge plasma deposition system previously used for treating flat substrates was successfully modified and optimized to produce a PEO‐like coating on the inner surface of 1–3 mm ID polyethylene tubing by deposition of tetra ethylene glycol dimethyl ether (tetraglyme). The plasma treatment conditions were varied in order to find operating values that would produce coatings with the ultralow (<5 ng/cm 2 ) fibrinogen adsorption (Γ Fg ) previously shown necessary to significantly reduce platelet adhesion. The flow rate of gaseous tetraglyme monomer, pressure, and plasma generating power were found to be the most important parameters affecting the uniformity and chemical structure of the coating. The coating uniformity and quality were assessed by measuring Γ Fg at positions 1 cm apart along the entire tube and the fraction of C1s carbon that was in an ether bond (ether–carbon ratio) by electron spectroscopy of chemical analysis. Under optimized conditions, tetraglyme plasma‐coated tubes of up to 20 cm in length had ultralow Γ Fg . The region of the tube that had ultralow Γ Fg also had C1s ether–carbon ratios that are greater than 50%. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007