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Preparation of bioactive nanotitania ceramics with biomechanical compatibility
Author(s) -
Yang B. C.,
Yu Q. F.,
Li Z. S.,
Qu Y.,
Huang Y.,
Chen J. Y.,
Gu Z. W.,
Zhang X. D.
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30869
Subject(s) - materials science , compatibility (geochemistry) , simulated body fluid , apatite , ceramic , particle size , composite material , sintering , biomedical engineering , nuclear chemistry , chemical engineering , mineralogy , scanning electron microscope , chemistry , medicine , engineering
Abstract In this article, bioactive nanotitania ceramics with biomechanical compatibility was prepared by using an additive of hydroxyapatite or MgO as particle growth inhibitor. After sintering at 1000°C, the particle size of nanotitania ceramics prepared by using HA as additive (HT) was much smaller than that prepared by using MgO as additive (MT). In simulated body fluid (SBF), HT could induce apatite formation in 4 days, while no apatite could be found on MT even after it was soaked in SBF for 14 days. After Ros17/28 osteoblasts were cultured on the materials for 1, 4, and 6 days, MTT results showed that the osteoblasts on the HT differentiated faster than that on the MT. Mechanical tests results showed that the bending and compressive strength of HT were 160 and 200 MPa, while those of MT were 70 and 88 MPa, respectively. These results demonstrated that it is suitable to prepare bioactive nanotitania ceramics, with biomechanical compatibility, by using HA as particle growth inhibitor. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006