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Electrospinning biomedical nanocomposite fibers of hydroxyapatite/poly(lactic acid) for bone regeneration
Author(s) -
Kim HaeWon,
Lee HaeHyoung,
Knowles J. C.
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30866
Subject(s) - materials science , bioceramic , electrospinning , nanocomposite , biopolymer , chemical engineering , polylactic acid , tissue engineering , lactic acid , composite material , polymer , biomedical engineering , medicine , biology , bacteria , engineering , genetics
Development of fibrous matrices of bioceramic–biopolymer nanocomposite offers great potential in the field of bone regeneration and tissue engineering. However, in order to produce electrospun fibers with homogeneous structure, it is essential for the ceramic powder to be fine and to remain stable in suspension. Herein, we developed a novel method whereby the bioceramic hydroxyapatite (HA) was kept in suspension in biopolymer poly(lactic acid) (PLA). The strategy was to introduce a surfactant hydroxysteric acid (HSA) between the hydrophilic HA powder and the hydrophobic chloroform‐dissolved PLA. The HA nanopowder was dispersed effectively in HSA and mixed homogeneously with PLA. Continuous and uniform fibers were generated successfully with diameters of ∼1–2 μm, and featured a well‐developed nanocomposite structure of HA nanopowder‐dispersed PLA. Initial cellular assays showed excellent cell attachment and proliferation and also enhanced expression of alkaline phosphatase at 7 days of culturing. The HA–PLA nanocomposite fibers may be potentially useful in tissue engineering applications, particularly as three‐dimensional substrates for bone growth. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006