Premium
Nanostructured niobium oxide coatings influence osteoblast adhesion
Author(s) -
Eisenbarth E.,
Velten D.,
Müller M.,
Thull R.,
Breme J.
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30823
Subject(s) - materials science , surface roughness , annealing (glass) , niobium , surface finish , adhesion , coating , titanium , osteoblast , niobium oxide , composite material , oxide , chemical engineering , metallurgy , in vitro , biochemistry , chemistry , engineering
The interaction of osteoblasts was correlated to the roughness of nanosized surface structures of Nb 2 O 5 coatings on polished CP titanium grade 2. Nb 2 O 5 sol–gel coatings were selected as a model surface to study the interaction of osteoblasts with nanosized surface structures. The surface roughness was quantified by determination of the average surface finish (Ra number) by means of atomic force microscopy. Surface topographies with Ra = 7, 15, and 40 nm were adjusted by means of the annealing process parameters (time and temperature) within a sol–gel coating procedure. The observed osteoblast migration was fastest on smooth surfaces with Ra = 7 nm. The adhesion strength, spreading area, and collagen‐I synthesis showed the best results on an intermediate roughness of Ra = 15 nm. The surface roughness of Ra = 40 nm was rather peaked and reduced the speed of cell reactions belonging to the adhesion process. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006