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Orally administered, colon‐specific mucoadhesive azopolymer particles for the treatment of inflammatory bowel disease: An in vivo study
Author(s) -
Roldo Marta,
Barbu Eugen,
Brown James F.,
Laight David W.,
Smart John D.,
Tsibouklis John
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30810
Subject(s) - in vivo , materials science , inflammatory bowel disease , intestinal mucosa , pharmacology , biomedical engineering , medicine , disease , biology , microbiology and biotechnology
Radiolabeled congeners of a series of azopolymers have been synthesized and characterized. The in vivo (rat) gastrointestinal transit profile of millimeter‐sized particles of these azopolymers has been determined and used to facilitate the selection of a candidate material for therapeutic applications. The efficacy of the selected material as a protective coating for the colonic mucosa has been tested in a hapten‐reactivated, in vivo model of inflammatory bowel disease: 7 days after reactivation of the condition, the myeloperoxidase activity of animals that had received doses of the selected azopolymer was determined to be at the same level as that of healthy animals or that of the negative control group, highlighting the therapeutic promise of this material. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006