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Antimicrobial effect of silver‐doped phosphate‐based glasses
Author(s) -
Ahmed I.,
Ready D.,
Wilson M.,
Knowles J.C.
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30808
Subject(s) - staphylococcus aureus , bacillus cereus , candida albicans , antimicrobial , escherichia coli , microbiology and biotechnology , materials science , corpus albicans , agar diffusion test , pseudomonas aeruginosa , nuclear chemistry , biology , bacteria , chemistry , biochemistry , genetics , gene
In this study a range of phosphate‐based glasses (PBG) doped with silver have been investigated for their antimicrobial activities. In disk diffusion assays, these compositions demonstrated microbistatic effects against a range of organisms including Staphylococcus aureus , Escherichia coli , Bacillus cereus , Pseudomonas aeruginosa , methicillin‐resistant Staphylococcus aureus , and Candida albicans . The data obtained from the above studies allowed for an additional range of PBG containing lower amounts of silver to be studied for their effects on the growth and viability of S. aureus , E. coli , and C. albicans . PBG containing 3 and 5 mol % Ag were bactericidal for S. aureus and E. coli and significantly decreased the growth rate of C. albicans. A decrease in the dissolution rates of the glasses was seen with increasing Ag content over the range of concentrations investigated. Overall, 3 mol % Ag incorporated into the PBG investigated was sufficient to mount a potent antibacterial effect against the test organisms, and these compositions also gave excellent long‐term release of Ag ions into the medium. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006