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Calcium carbonate–calcium phosphate mixed cement compositions for bone reconstruction
Author(s) -
Combes C.,
Bareille R.,
Rey C.
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30795
Subject(s) - materials science , apatite , cement , vaterite , chemical engineering , calcium carbonate , calcium , mineralogy , compressive strength , amorphous calcium phosphate , aragonite , solubility , composite material , metallurgy , chemistry , organic chemistry , engineering
The feasibility of making calcium carbonate–calcium phosphate (CaCO 3 –CaP) mixed cements, comprising at least 40% (w/w) CaCO 3 in the dry powder ingredients, has been demonstrated. Several original cement compositions were obtained by mixing metastable crystalline CaCO 3 phases with metastable amorphous or crystalline CaP powders in aqueous medium. The cements set within at most 1 h at 37°C in atmosphere saturated with water. The hardened cement is microporous and exhibits weak compressive strength. The setting reaction appeared to be essentially related to the formation of a highly carbonated nanocrystalline apatite phase by reaction of the metastable CaP phase with part or almost all of the metastable CaCO 3 phase. The recrystallization of metastable CaP varieties led to a final cement consisting of a highly carbonated poorly crystalline apatite analogous to bone mineral associated with various amounts of vaterite and/or aragonite. The presence of controlled amounts of CaCO 3 with a higher solubility than that of the apatite formed in the well‐developed CaP cements might be of interest to increase resorption rates in biomedical cement and favors its replacement by bone tissue. Cytotoxicity testing revealed excellent cytocompatibility of CaCO 3 –CaP mixed cement compositions. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006