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Crystallochemistry, textural properties, and in vitro biocompatibility of different silicon‐doped calcium phosphates
Author(s) -
Arcos D.,
SánchezSalcedo S.,
IzquierdoBarba I.,
Ruiz L.,
GonzálezCalbet J.,
ValletRegí M.
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30790
Subject(s) - apatite , materials science , biocompatibility , nanocrystalline material , silicon , calcium , doping , microstructure , chemical engineering , phosphate , nanocrystalline silicon , bioceramic , mineralogy , nanotechnology , composite material , crystalline silicon , metallurgy , chemistry , organic chemistry , amorphous silicon , optoelectronics , engineering
Three silicon‐doped calcium phosphates (Si‐CaPs) were synthesized by heating precipitated silicon‐doped apatite via different thermal treatments. Temperatures of 700°C, 900°C, and 1100°C led to an apatite‐glass biphasic material, nanocrystalline Si‐doped apatite (SiHA), and Si‐doped apatite‐α tricalcium phosphate biphasic material, respectively. Structure, microstructure, textural properties, and chemical differences were determined for the three bioceramics. Biocompatibility tests were carried out by seeding osteblast‐like cells onto the three substrates. Si‐CaP treated at 700°C and 900°C led to Ca decrease in the culture media, partially impeding the cell proliferation over them. However, the proliferation capability is restored when additional culture medium is added. Finally, cytotoxicity results indicated that cell damage is much lower in osteblast‐like cells seeded onto SiHA and SiHA‐α tricalcium phosphate samples than in plastic culture control. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006