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A mouse strain difference in tumorigenesis induced by biodegradable polymers
Author(s) -
Ahmed Saifuddin,
Tsuchiya Toshie
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30753
Subject(s) - extracellular matrix , connexin , in vivo , materials science , carcinogenesis , microbiology and biotechnology , lactic acid , strain (injury) , growth factor , extracellular , cancer research , intracellular , gap junction , biology , biochemistry , anatomy , bacteria , gene , genetics , receptor
The use of poly‐ L ‐lactic acid (PLLA) surgical implants for repair of bone fractures has gained popularity in the past decade. The aim of this study was to evaluate the in vivo effect of PLLA plates on subcutaneous tissue in two mouse strains, BALB/cJ and SJL/J, which have higher and lower tumorigenicity, respectively. Gap‐junctional intercellular communication and protein expression of connexin 43 were significantly suppressed, whereas secretion of transforming growth factor‐β1 and expression of extracellular matrix, insulin‐like growth factor binding protein 3, and cysteine‐rich intestinal protein 2 were significantly increased in PLLA‐implanted BALB/cJ mice when compared with BALB/cJ controls. Finally, tumors were formed after implantation of cultured cells from the more‐tumorigenic BALB/cJ, but not SJL/J, mice into nude mice. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006