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Hydrophilic molecularly imprinted poly(hydroxyethyl‐methacrylate) polymers
Author(s) -
Oral Ebru,
Peppas Nicholas A.
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30725
Subject(s) - methacrylate , materials science , polymer , molecularly imprinted polymer , ethylene glycol , polymer chemistry , 2 hydroxyethyl methacrylate , molecular imprinting , solvent , ethylene glycol dimethacrylate , (hydroxyethyl)methacrylate , drug delivery , chemical engineering , template , monomer , organic chemistry , methacrylic acid , chemistry , catalysis , selectivity , nanotechnology , engineering , composite material
Highly cross‐linked 2‐hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) dimethacrylate with poly(ethylene glycol) of molecular weight 600 (PEG600DMA) were molecularly imprinted with hydrophilic templates glucose and proxyphylline using water as a solvent. Glucose‐imprinted polymers showed increased recognitive capacity compared to nonimprinted polymers as well as increased glucose uptake compared to structurally similar galactose and methylglucopyranoside. Increasing glucose concentration in the imprinting mixture resulted in higher capacity and selective binding. Similar results were obtained for proxyphylline‐imprinted P(HEMA‐co‐PEG600DMA) polymers, where the proxyphylline uptake was higher than structurally similar theophylline. Glucose‐imprinted networks also showed diffusion coefficients on the order of 10 −6 cm 2 /s, conducive to applications in drug delivery and tissue engineering. This work showed that using pairs of hydrogen‐bonding monomers and templates, selective, high‐affinity sites could be created despite nonspecific binding. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006