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Subcutaneous evaluation of RF magnetron‐sputtered calcium pyrophosphate and hydroxylapatite‐coated Ti implants
Author(s) -
Yonggang Yan,
Wolke J.G.C.,
Yubao Li,
Jansen J.A.
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30674
Subject(s) - materials science , hydroxylapatite , scanning electron microscope , titanium , calcium pyrophosphate , dissolution , apatite , calcium , composite material , metallurgy , chemical engineering , mineralogy , chemistry , biochemistry , engineering , enzyme
Abstract The in vivo behavior of infrared‐heated, RF magnetron‐sputtered hydroxylapatite (HA) and calcium pyrophosphate (DCPP) coated titanium discs was investigated. The discs were implanted subcutaneously in the back of six goats for 2, 4, 8 and 12 weeks. At the end of the study, coated discs were removed and examined on their physicochemical properties by X‐ray diffraction (XRD) and scanning electron microscopy (SEM), including energy dispersive spectroscopy (EDS). Also, implants were prepared for light microscopical evaluation of the tissue response. The results showed that heat‐treated HA coatings showed a stable behavior, i.e. no changes in the XRD pattern occurred during implantation. Also, no dissolution of the coating was observed by SEM. EDS revealed that the Ca/P ratio of the HA coatings remained stable during implantation. In contrast, heat‐treated DCPP coatings showed a compositional change into apatite and tricalcium phosphate (TCP) during implantation. This was confirmed by the SEM and EDS analysis. The Ca/P ratio of the DCPP coatings changed from 0.8 to 1.52 during implantation. Finally, histology showed that both heat‐treated HA and DCPP coatings showed no adverse tissue response, as characterized by the presence of thin, dense fibrous tissue capsule. Consequently, it can be concluded that 2 μm thick heat‐treated, RF magnetron‐sputtered HA and DCPP coatings are of sufficient thickness to withstand dissolution during 12 weeks of implantation in a subcutaneous location in goats. In addition, both coatings showed a biocompatible tissue behavior. Further, heat‐treated DCPP coatings revealed a gradual compositional change into apatite and TCP. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006