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Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: Synthesis, in vitro assessment, and in vivo evaluation
Author(s) -
Verestiuc Liliana,
Nastasescu Oana,
Barbu Eugen,
Sarvaiya Indrajeetsinh,
Green Keith L.,
Tsibouklis John
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30668
Subject(s) - chitosan , materials science , methacrylate , drug delivery , bioadhesive , self healing hydrogels , 2 hydroxyethyl methacrylate , in vivo , swelling , interpenetrating polymer network , polymer , monomer , (hydroxyethyl)methacrylate , pilocarpine , polymer chemistry , nanotechnology , organic chemistry , chemistry , composite material , medicine , microbiology and biotechnology , biology , psychiatry , epilepsy
A series of hybrid polymeric hydrogels, prepared by the reaction of acrylic acid‐functionalized chitosan with either N ‐isopropylacrylamide or 2‐hydroxyethyl methacrylate monomers, were synthesized, pressed into minitablets, and investigated for their ability to act as controlled release vehicles for ophthalmic drug delivery. For comparison, interpolymeric complex analogues synthesized using the same monomers and pure, unfunctionalized chitosan were examined by means of an identical characterization protocol. The effects of network structure and composition upon the swelling properties, adhesion behavior, and drug release characteristics were investigated. Comparative in vitro studies employing chloramphenicol, atropine, norfloxacin, or pilocarpine informed the selection of drug‐specific carrier compositions for the controlled delivery of these compounds. In addition, in vivo (rabbit model) experiments involving the delivery of pilocarpine indicated that chitosan‐based hybrid polymer networks containing 2‐hydroxyethyl methacrylate are useful carriers for the delivery of this therapeutic agent. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res 2006