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Study of recombinant human osteogenic protein‐1 expressed in prokaryocyte on the repair of extracted socket in rabbits
Author(s) -
Liu Yi,
Han JinXiang,
Xiao ShuiQing,
Wang ShiLi,
Wang Min
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30565
Subject(s) - alkaline phosphatase , bone healing , recombinant dna , biomedical engineering , materials science , histology , calcium , gelatin , wound healing , dentistry , anatomy , pathology , surgery , biochemistry , biology , medicine , enzyme , metallurgy , gene
The study investigated the effect of recombinant human osteogenic protein‐1 (rhOP‐1) expressed in prokaryocyte, to promote the healing of alveolar socket. A model of rabbit extracted socket into which the composites of rhOP‐1 and gelatin sponge was immediately implanted was created and the osteoinduction of rhOP‐1 was assessed by histological method, quantitative measurement of calcium content and alkaline phosphatase (ALP) activity. The result of histology showed that bone healing in rhOP‐1 side is 4–6 weeks earlier than that of the control side. ALP activity and calcium content in rhOP‐1 side were significantly high compared with that of the control side. rhOP‐1 has a satisfactory osteoinduction ability to promote the healing of extracted socket. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006