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Bioactive glass/polymer composite materials with mechanical properties matching those of cortical bone
Author(s) -
Koleganova Veronika A.,
Bernier Suzanne M.,
Dixon S. Jeffrey,
Rizkalla Amin S.
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30561
Subject(s) - materials science , bioactive glass , silane , composite material , biocompatibility , polymer , composite number , methacrylate , cortical bone , copolymer , medicine , metallurgy , anatomy
Stress shielding resulting from mismatch in dynamic mechanical properties contributes to the reduced stability of osseous implants. Our objective was to develop biocompatible composites having mechanical properties similar to those of cortical bone. Polymers of urethane dimethacrylate (UDMA) and 2‐hydroxyethyl methacrylate (HEMA, 0–20%) and composites containing bioactive glass particles (70% SiO 2 , 25% CaO, and 5% P 2 O 5 ), with or without silane treatment were prepared. Young's moduli of composites containing silane‐treated glass (16 GPa) were significantly greater than those of composites containing untreated glass (12–13 GPa) or of unfilled polymers (5–6 GPa). Bioactive glass reduced water sorption by the composites and incorporation of silane‐treated glass prevented HEMA‐induced increases in water sorption. Osteoblast‐like cells attached equally well to UDMA polymer and composite containing silane‐treated bioactive glass. Thus, silane treatment improved the mechanical properties of bioactive glass composites without compromising biocompatibility. This material has a Young's modulus comparable to that of cortical bone. Therefore, silane‐treated bioactive glass composites, when used as implant or cement materials, would reduce stress shielding and improve implant stability. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006