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Fluorinated diamond‐like carbon as antithrombogenic coating for blood‐contacting devices
Author(s) -
Hasebe Terumitsu,
Shimada Atsushi,
Suzuki Tetsuya,
Matsuoka Yoshiaki,
Saito Toshiya,
Yohena Satoshi,
Kamijo Aki,
Shiraga Nobuyuki,
Higuchi Mutsumi,
Kimura Kanako,
Yoshimura Hirokuni,
Kuribayashi Sachio
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30512
Subject(s) - materials science , biocompatibility , coating , diamond like carbon , biomedical engineering , platelet activation , composite material , platelet , nanotechnology , thin film , metallurgy , medicine , immunology , biology
Diamond‐like carbon (DLC) is being considered for widespread clinical use as a surface coating for cardiovascular devices. We synthesized fluorinated DLC (F‐DLC) coatings in order to create a more hydrophobic surface with improved antithrombogenicity and flexibility when compared with conventional DLC coatings by combining the inertness of DLC films with the advantage of fluorination. The purpose of this study was to evaluate the in vitro hemocompatibility and in vivo biocompatibility of the F‐DLC coating for medical devices. The in vitro whole blood model confirmed that platelet loss was lower in the F‐DLC group than in the noncoated group (SUS316L), which suggests the adhesion of a smaller number of platelets to F‐DLC‐coated materials. Furthermore, the biomarkers of mechanically induced platelet activation (beta‐thromboglobulin) and activated coagulation (thrombin‐antithrombin‐three complex) were markedly reduced in the F‐DLC‐coated group. In vivo rat implant model studies revealed no excessive local and systemic inflammatory responses in the F‐DLC group. The thickness of the fibrous tissue capsule surrounding the F‐DLC‐coated disk was almost equal to that of the noncoated SUS316L disk, which has the favorable biocompatibility for metallic implant materials. F‐DLC coating thus appears to be a promising candidate for use as a coating material in blood‐contacting devices. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2006