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Urokinase‐immobilization suppresses inflammatory responses to polyurethane tubes implanted in rabbit muscles
Author(s) -
Lai ZhongFang,
Imamura Takahisa,
Koike Norio,
Kitamoto Yasunori
Publication year - 2006
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30500
Subject(s) - urokinase , materials science , thrombus , polyurethane , plasmin , adhesion , fibrosis , biomedical engineering , medicine , surgery , chemistry , biochemistry , composite material , enzyme
Urokinase and plasmin appear to have antiinflammatory activity in some injury models, and urokinase immobilization has been clinically used to prevent thrombus formation in various implants, including intravenous indwelling catheters and subcutaneous drainage tubes. In the present study, polyurethane tubes were embedded in rabbit muscle for 3 months and the effect of urokinase immobilization on inflammatory responses to the implanted tubes was studied at 1 week, 1 month, and 3 months. Mononuclear leukocyte accumulation occurred around implanted polyurethane tubes and peaked after 1 month, but was reduced significantly by urokinase immobilization. The treatment also lessened as well as delayed eosinophil accumulation, but did not affect fibrosis caused by implanted tubes. These results indicate suppressive effects of urokinase immobilization on polyurethane‐elicited inflammatory responses and suggest that an approach to develop persistently active urokinase immobilization is rational for successful long‐term device implantation. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2006