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Hydrolytic degradation behavior of biodegradable polyetheresteramide‐based polyurethane copolymers
Author(s) -
Liu CaiBing,
Gu YingChun,
Qian ZhiYong,
Fan LinYu,
Li Jun,
Chao GuoTao,
Tu MingJing,
Jia WenJuan
Publication year - 2005
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30453
Subject(s) - materials science , extender , copolymer , polyurethane , hydrolysis , degradation (telecommunications) , ethylene glycol , polymer chemistry , hydrolytic degradation , polyester , condensation polymer , toluene , absorption of water , chemical engineering , polymer , organic chemistry , composite material , chemistry , telecommunications , computer science , engineering
In this article, a new kind of biodegradable polyetheresteramide‐based polyurethane (PEEA‐U) copolymers were prepared by the melt polycondensation method from ϵ‐caprolactone, 6‐aminocaproic acid, poly(ethylene glycol), and toluene diisocyanate. The water absorption of PEEA‐U was affected strongly by the reaction time and the content of chain extender; and the hydrolytic degradation behavior of the copolymers was mainly determined by the reaction time, chain extender content, and the pH value of the degradation medium. Also, DSC, 1 H‐NMR, and inherent viscosity were used to characterize the degradation behavior of the copolymers. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005