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Development of an infection‐resistant bifunctionalized Dacron biomaterial
Author(s) -
Aggarwal Puja,
Phaneuf Matthew D.,
Bide Martin J.,
Sousa Kerry A.,
LoGerfo Frank W.
Publication year - 2005
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30427
Subject(s) - antimicrobial , dyeing , biomaterial , materials science , polyethylene terephthalate , polyester , ethylenediamine , antibiotics , amine gas treating , biomedical engineering , ciprofloxacin , microbiology and biotechnology , nuclear chemistry , composite material , organic chemistry , biology , medicine , nanotechnology , chemistry
A novel infection‐resistant biomaterial was created by applying the antibiotic Ciprofloxacin (Cipro) to a recently developed bifunctionalized polyethylene terephthalate (“polyester,” Dacron) material using textile‐dyeing technology. Dacron was modified via exposure to ethylenediamine (EDA) to create amine and carboxylic acid sites within the polymer backbone. Cipro was applied to the bifunctionalized Dacron construct under varied experimental conditions, with resulting antimicrobial activity determined via zone of inhibition. Dacron segments treated at a liquor ratio of 20:1, with 5% Cipro o n w eight of f abric (owf), at pH 8 for 4 h at 70°C followed by autoclaving showed antimicrobial activity for 78 days (length of study). Segments treated similarly but without autoclaving lost activity within 1 day. Dyeing time and temperature did not significantly affect antibiotic release/activity, but segments dyed at pHs higher or lower than 8 had less antimicrobial activity. The long‐term infection resistance provided by this technique may answer major problems of infection from which implantable Dacron biomedical devices suffer. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005