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Improving delivery of hydrophobic drugs from hydrogels through cyclodextrins
Author(s) -
Kanjickal Deenu,
Lopina Stephanie,
EvanchoChapman M. Michelle,
Schmidt Steven,
Donovan Duane
Publication year - 2005
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30374
Subject(s) - materials science , self healing hydrogels , drug delivery , cyclodextrin , nanotechnology , organic chemistry , polymer chemistry , chemistry
Abstract A simple and effective technique of improving delivery of hydrophobic drugs from swellable systems is presented. Conventional methods of drug loading in hydrogel systems are limited by the characteristics of the pharmacological agent. The approach we present uses complexants to modulate drug release. Crosslinked poly(ethylene glycol) (PEG) hydrogels were synthesized, characterized, and used for vascular applications. The release of cyclosporine (CyA) from PEG hydrogels is significantly altered by the sterilization techniques. It was hypothesized that the release of CyA from PEG hydrogels can be modulated by using complexants. A cyclodextrin–CyA complex solution was prepared and used for drug loading. The sterilized PEG hydrogels that were loaded using the cyclodextrin–CyA complex solution had favorable release characteristics compared with the release from PEG hydrogels that were loaded using the conventional technique. Hence, drug release from swellable systems can be tailored by the application of this strategy. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005