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Interaction of cells with L ‐lactide/glycolide copolymers synthesized with the use of tin or zirconium compounds
Author(s) -
Czajkowska Barbara,
Dobrzynski Piotr,
Bero Maciej
Publication year - 2005
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30325
Subject(s) - materials science , copolymer , tin , lactide , zirconium , chemical engineering , polymer chemistry , composite material , polymer , metallurgy , engineering
Abstract Comparative studies have been carried out on the viability of cells culture and production of collagen on lactide/glycolide copolymers synthesized using zirconium or tin initiators. Cell response of various cell types: fibroblast‐like cells, osteoblast‐like cells, monocyte/macrophage‐like cells has been examined. Cell response depends on the kind of cells and the initiator used during the synthesis of the polymer. In a number of cases the cells grown on materials containing zirconium have been reported to have better survival (for example, Saos2 cells). An enhanced collagen production on these copolymers has been also observed. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005