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Surface modification of metallic cardiovascular stents by strongly adhering aliphatic polyester coatings
Author(s) -
Jérôme Christine,
Aqil Abdelhafid,
Voccia Samuël,
Labaye DavidEmmanuel,
Maquet Véronique,
Gautier Sandrine,
Bertrand Olivier F.,
Jérôme Robert
Publication year - 2005
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30256
Subject(s) - materials science , polyester , scanning electron microscope , biodegradable polymer , raman spectroscopy , monomer , biocompatibility , polymer chemistry , chemical engineering , coating , polymer , nanotechnology , composite material , metallurgy , physics , optics , engineering
This article reports on a novel two‐step strategy for the coating of cardiovascular stents by strongly adhering biocompatible and biodegradable aliphatic polyesters. First, a precoating of poly(ethylacrylate) (PEA) was electrografted onto the metallic substrate by cathodic reduction of the parent monomer in dimethylformamide (DMF). The electrodeposition of PEA, in a good solvent of it, was confirmed by both Infra‐red and Raman spectroscopies. The pendant ester groups of PEA were then chemically reduced into aluminum alkoxides, able to initiate the ring‐opening polymerization (ROP) of either D , L ‐lactide (LA) or ϵ‐caprolactone (CL). Growth of biodegradable PLA or PCL coatings from the adhering precoating was confirmed by both Infra‐red and Raman spectroscopies, and directly observed by scanning electron microscopy (SEM). This type of coating can act as an anchoring layer for the subsequent casting of drug‐loaded polyester films allowing the controlled release of antiproliferative agents for the treatment of in‐stent restenosis. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2006