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A novel covalently crosslinked gel of alginate and silane with the ability to form bone‐like apatite
Author(s) -
Hosoya Kayo,
Ohtsuki Chikara,
Kawai Takahiro,
Kamitakahara Masanobu,
Ogata Shinichi,
Miyazaki Toshiki,
Tanihara Masao
Publication year - 2004
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30189
Subject(s) - silanol , simulated body fluid , apatite , materials science , carbodiimide , silane , chemical engineering , biomaterial , covalent bond , polymer chemistry , polymer , chemistry , organic chemistry , composite material , nanotechnology , catalysis , engineering
Hybrids consisting of bone‐like apatite and biodegradable polymers are attractive materials for bone repair. We have shown that an alginate gel crosslinked covalently with ethylenediamine (EDA) enhances the repair of skin and nerves. In this study, we report a novel method for fabrication of an apatite–alginate nanohybrid using a simulated body fluid (SBF). Alginate was reacted with 3‐aminopropyltriethoxysilane (APES), which gives silanol groups after hydrolysis, and/or EDA, by dehydration condensation using water‐soluble carbodiimide to form gels. Modification of alginate with APES alone also gave a gel, because the alginate could be crosslinked by dehydration of silanol groups derived from APES. The gels obtained were soaked in a 1 mol/L CaCl 2 solution and subsequently soaked in SBF. Apatite was formed on and inside the alginate gels modified with APES, whereas it was not formed on the gels without APES. Modification of alginate with silanol groups induced not only gel formation but also the apatite‐forming ability on and inside the alginate gel in SBF. Consequently, a hydroxyapatite–alginate hybrid can be produced by modification of alginate with silanol groups and subsequent soaking in CaCl 2 solution and SBF. Such a material is expected to be useful in bone repair. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 71A: 596–601, 2004