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The potential calcification of octacalcium phosphate on intraocular lens surfaces
Author(s) -
Guan Xiangying,
Tang Ruikang,
Nancollas George H.
Publication year - 2004
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30176
Subject(s) - octacalcium phosphate , carboxylate , calcification , materials science , aqueous solution , phosphate , crystallization , chemistry , organic chemistry , medicine , pathology
Recently, calcification was observed on implanted intraocular lens (IOL) surfaces when viscoelastic substances were applied during surgery. To elucidate the mechanisms of mineral formation, the crystallization of calcium phosphates on IOL surfaces was studied in vitro with nanomolar sensitivity using a constant composition method. Three different commercial viscoelastic materials (Viscoat®, OcuCoat®, and Amvisc® Plus) were investigated and it was found that some IOLs treated with Viscoat® or Amvisc® Plus induced the nucleation and growth of octacalcium phosphate crystallites under biological conditions. After treatments, the IOL surfaces became more hydrophilic probably because of the high viscoelastic phosphate and carboxylate contents. In contrast to Viscoat®, the use of OcuCoat® during surgery resulted in virtually no octacalcium phosphate nucleations. Calcification studies of IOL surfaces treated with fatty acids, which are present in human aqueous humor, suggest that hydrophobic cyclic silicones adsorbed on the IOL surfaces interact strongly with hydrophobic hydrocarbon chains of the fatty acids, creating a layer of amphiphiles oriented with functional carboxylate groups exposed to the aqueous solution and serving as active calcification sites. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 71A: 488–496, 2004