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Water uptake and release from iodine‐containing bone cement
Author(s) -
Kjellson F.,
Brudeli B.,
McCarthy I. D.,
Lidgren L.
Publication year - 2004
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30162
Subject(s) - iodixanol , iohexol , materials science , radiodensity , cement , diffusion , biomedical engineering , medicine , composite material , contrast medium , radiology , radiography , physics , renal function , thermodynamics
Water uptake and release characteristics of PMMA cement containing the water‐soluble contrast media iohexol or iodixanol have been investigated. The water uptake study revealed that iohexol had the highest uptake of water (3.7%) and that iodixanol had an uptake close to that of Palacos® R (2.3% and 1.9%). The curves obtained showed the materials to follow classic diffusion theory, with an initial linearity with respect to t 1/2 making it possible to calculate the diffusion coefficients. This showed iohexol to have the lowest diffusion coefficient, Palacos® R the highest, and iodixanol close to that of Palacos® R. The release study showed that more iohexol than iodixanol was released from the bone cement; the long‐term release was above 25 μg/mL for iohexol compared to slightly above 10 μg/mL for iodixanol. A μCT investigation showed that the risk of developing an observable radiolucent zone is negligible. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 71A: 292–298, 2004